Varicose veins are tortuous, widened veins in the subcutaneous tissues of the legs and are often easily visible. Their valves are usually incompetent so that reflux of blood occurs, and the resulting venous hypertension. Varicose veins are widely seen as medically unimportant and deserving low priority for treatment. For the great majority of people varicose veins cause no symptoms and never cause harm. The primary cause of varicose vein formation is not clear. Epidemiological studies indicate involvement of hereditary factors . Both vein valve dysfunction and hydrostatic venous pressure appear to play a critical role in the initiation and progression of the disease. The role of imbalance of certain metalloproteinases are thought to play some significant role in the development of varicose veins and hence the study aimed to investigate the role of matrix metalloproteinases (MMPs) imbalance in development of varicosity.