To Study Enzyme Imbalance for the Development of Varicosity in Young Adult Male Population of South India

International Journal of Research in Health Sciences,2013,1,3,122-125.
Published:October 2013
Type:Original Article
Author(s) affiliations:

Remya K1, Rajesh Ballal2, Sunil Kumar Y3 

1-Lecturer, Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, INDIA. 

2-Professor, Department of Surgery, KSHEMA, Nitte University,Mangalore, Karnataka, INDIA. 

 3-Associate professor, Department of pathology, KSHEMA, Nitte University, Mangalore, 

Karnataka, INDIA. 


Varicose veins are tortuous, widened veins in the subcutaneous tissues of the legs and are often easily visible. Their valves are usually incompetent so that reflux of blood occurs, and the resulting venous hypertension. Varicose veins are widely seen as medically unimportant and deserving low priority for treatment. For the great majority of people varicose veins cause no symptoms and never cause harm. The primary cause of varicose vein formation is not clear. Epidemiological studies indicate involvement of hereditary factors . Both vein valve dysfunction and hydrostatic venous pressure appear to play a critical role in the initiation and progression of the disease. The role of imbalance of certain metalloproteinases are thought to play some significant role in the development of varicose veins and hence the study aimed to investigate the role of matrix metalloproteinases (MMPs) imbalance in development of varicosity.

Readings from cases and controls of MMP