Ischemic Heart Disease forms one of the commonest causes of morbidity and premature death in the community, both in India as well as abroad especially in the young aged individuals. The incidence of this disease is about 9.7% of the total population globally. Advancing Age, Family history of premature myocardial infarction, Diabetes Mellitus, Systolic Blood Pressure, Smoking, Increased LDL-Cholesterol levels, Decreased HDL-Cholesterol and hypertriglyceridemia are the well known risk factors which will predispose for the coronary artery disease. Certain novel risk factors such as Lipoprotein-A, Homocysteine, fibrinogen and C - reactive protein are also found associated with the incidence of Ischemic Heart disease. Estimation of these risk factors will pave for early detection and prompt management of Ischemic Heart Disease and its complications. The current study aimed at determining the relationship between total plasma homocysteine as an independent causative agent of ischemic heart disease in young patients and also of elevation of serum cardiac markers like CK and CK-MB in cases of Acute Myocardial Infarction. From the study it is concluded that the raised homocysteine, CK, CK-MB levels and raised lipids other than HDL-C are definitive risk factors for Ischemic heart disease.