Background: To study the primary and secondary lymph node malignancy on Fine Needle Aspiration Cytology (FNAC). Material and Method: A retrospective and prospective study of lymphadenopathy cases on FNAC reported in the Department of Pathology at our institute from October 2015 to May 2016. Results: The total of 217 FNAC were done of enlarged lymph nodes. Metastases were seen in 70/217 cases (32.26 %), Primary lymphoid malignancies were seen in 10/217cases (4.61%). The non-neoplastic lesions were seen in 137/217 (63.13%) cases. The most common metastatic malignancy was squamous cell carcinoma (SCC) 42/70 cases (60%), followed by duct carcinoma 12/70 cases (17.14%), metastatic adenocarcinoma cases 10/70 (14.28%). The common site involved was cervical group of lymph node in 65/80 cases (81.25%) for lymph node malignancies. Conclusion: FNAC of lymphadenopathy is a useful method for diagnosing primary and secondary malignancies of lymph node. In our study most common age group affected by malignant lesions was 61-70 years with male predominance. The most common metastatic lesion observed was squamous cell carcinoma. The cervical group of lymph node was the common site for metastatic lesions.