Comparison of Topical Application of Ketamine Aspirin and Lignocaine on Effects of Intubation

International Journal of Research in Health Sciences,2014,2,4,1050-1056.
Published:October 2014
Type:Original Article
Author(s) affiliations:

M.N Satish Kumar1, Vidya C Madgaonkar2, T.N.Srikantamurthy3, Sharavanan E4 

1-Assistant professor, Dept of Anaesthesiology, M.S.Ramaiah Medical College Research Institute, Bengaluru- 560054, Karnataka, INDIA.

2-Professor, Dept of Anaesthesiology, BMCRI, Bengaluru, Karnataka, INDIA. 

3-Professor and Head of Department, Dept Of Anaesthesiology, BMCRI, Bengaluru, Karnataka, INDIA. 

4-Assistant Professor, Dept of Community Medicine, PESIMSR, Kuppam, Karnataka, INDIA.


Background: Postoperative sore throat, cough, and hoarseness of voice can contribute to post operative morbidity and patient dissatisfaction. Besides pain and nausea these are the most frequent subjective complaints. Objective: To determine and compare the effects of Ketamine gargle, Aspirin gargle and 10% Lignocaine spray on reducing the incidence and severity of post operative sore throat, cough and hoarseness. Materials and methods: Patients were randomly allocated in to three groups of 50 patients each. In group K (40mg Ketamine diluted in 29 ml of normal saline), group A (350mg of soluble Aspirin diluted in 30 ml of distilled water) and in group L (3 puff of 10% Lignocaine was sprayed before intubation). Results: The incidence of sore throat at 2nd hour was 20%(K), 24%(A) and 22%(L); cough was 20%(K), 12%(A) and 20%(L). All the patients were free of hoarseness in first 2 hours. At 4th hour the incidence of sore throat was 24%(K), 24%(A) and 26%(L); cough was 16%(K), 18%(A) and 20%(L) and in group K and A only 4% patients had hoarseness of grade 2 severity whereas in L group 6% patients had hoarseness of grade 3 severity. At 24th hour the incidence and severity was decreased to 8%(K), 10%(A) and 10%(L) for sore throat; 4%(K), 6%(A) and 4%(L) for cough and all the patients were free of hoarseness at 24th hour. Conclusions: All the three drugs were equally effective in reducing the incidence and severity of post operative sore throat, cough and hoarseness without causing drug related side effects.

Comparison of incidence of Sore throat in three groups of patients